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DNMT1 (DNA Methyl Transferase-1) Mouse anti-Human, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612618

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Catalog No. BDB612618


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Description

Description

DNA methylation of the 5 ft. position of the cytosine ring within CpG dinucleotides is essential for embryonic development. This methylation may affect transcriptional repression, formation of compact chromatin structures, X chromosome inactivation, and imprinting control. Three important DNA (Cytosine-5) methyltransferases (DNMTs) include DNMT1, DNMT3A, and DNMT3B. DNMT1 contains an N-terminal regulatory domain that may target it to replication foci, and a C-terminal catalytic domain that is homologous to bacterial cystosine 5-methylases. DNMT1 knockout mice have reduced DNA methylation, defects in imprinting, and derepression of endogenous retroviruses, and are embryonic lethal. DNMT1 is responsible for DNA methylations that occur after replication, while DNMT3A and DNMT3B act to establish new methylation patterns during embryogenesis. DNMT1 and DNMT3A are expressed in most fetal tissues, while DNMT3B is expressed only in fetal liver. All of these DNMTs are found in various adult tissues and show increased expression in some tumors and cancer cell lines. Thus, DNMT methylation of CpG dinucleotides is important for regulating DNA structure during development. This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or repoerted in the literature.

Immunofluorescence, Western Blotting

Specifications

Specifications

DNMT1 (DNA Methyl Transferase-1)
18
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2b
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
DNA Methyl Transferase-1
Affinity Purified
Human DNMT1 aa. 476-670
50μg
Cell Biology
Primary
Human
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