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DNMT3L Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA131714

Catalog No. PIPA131714


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Description

Description

PA1-31714 detects Dnmt3L from human samples. PA1-31714 has been successfully used in immunoprecipitation, Western blot applications. The PA1-31714 immunogen is: Synthetic peptide: C-GLLQRRRKWRSQL conjugated to KLH, corresponding to amino acids 152-164 of Human DNMT 3L.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.
Specifications

Specifications

DNMT3L
Polyclonal
Unconjugated
DNMT3L
Liquid
DNMT3L
synthetic peptide C-GLLQRRRKWRSQL conjugated to KLH, corresponding to amino acids 152-164 of Human DNMT 3L.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Immunoprecipitation, Western Blot
0.6 mg/mL
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Q9UJW3, Q9CWR8
MGC1090
Rabbit
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
29947, 54427
Documents
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