DOK1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527464
PA5-27464 targets DOK1 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27464 immunogen is recombit fragment corresponding to a region within amino acids 9 and 277 of Human DOK1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
|Recombit fragment corresponding to a region within amino acids 9 and 277 of Human DOK1|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|P62DOK, Downstream of tyrosine kinase 1, docking protein 1, docking protein 1 (downstream of tyrosine kinase 1), p62(dok), pp62|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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