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Dopamine beta Hydroxylase Sheep anti-Bovine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA3925

Catalog No. PA3-925


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Description

Description

PA3-925 detects human, bovine, rat and mouse DBH. This antibody is not effective for immunohistochemistry in human brain. PA3-925 has been successfully used in Western blot, immunohistochemistry and immunofluorescence procedures. By Western blot, this antibody detects an ~72 kDa protein representing DBH from rat neurons. In immunohistochemistry and immunofluorescence procedures, it specifically stains chromaffin cells of the adrenal medulla, and DBH containing cells of the sympathetic nervous system. The PA3-925 immunogen is a synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH. This sequence is highly conserved (>85% homology) in human, bovine and mouse.

DBH (Dopamine-Beta-hydroxylase) is an oxidoreductase belonging to the copper Type II, ascorbate dependent monooxygenase family. DBH is the enzyme responsible for conversion of dopamine to noradrenaline. Tissue specificity consists of chromaffin granules of the adrenal medulla and synaptic vesicles of the sympatheic nervous system. It exists as both a soluble and membrane-bound form in chromaffin granules.
Specifications

Specifications

Dopamine beta Hydroxylase
Polyclonal
whole serum with 0.05% sodium azide
P15101, P09172, Q64237, Q05754
Dopamine-Beta-hydroxylase
Sheep
IgG
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Unconjugated
DBH
Liquid
DBH
Synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
13166, 1621, 25699, 280758
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