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Doublecortin Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 481200

Catalog No. 48-120-0


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Description

Description

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.

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Specifications

Specifications

Doublecortin
Polyclonal
Unconjugated
DCX
Liquid
DCX
Synthetic peptide derived from the C-terminal region of the human doublecortin protein
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.25 mg/mL
PBS with 0.1% sodium azide; pH 7.4
O43602, O88809, Q9ESI7
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Rabbit
IgG
100 μg
-20°C
Primary
13193, 1641, 84394
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