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DR3 Mouse anti-Human, Mouse, Clone: 59204, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523838

Catalog No. PIMA523838


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Description

Description

This antibody shows 100% cross-reactivity with recombit mouse (rm) DR3/TNFRSF25 and no cross-reactivity with recombit human (rh) 4-1BB, rhCD27, rhCD30, rhCD40, rhDR6, rhBAFF R, rhFas, rhGITR, rhLTR beta, rhNGF R, rhOPG, rmOX40, rhRANK, rhTAJ, rhTNF RI, rhTNF RII, or rhHVEM. Reconstitute at 0.5 mg/mL in sterile PBS.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predomitly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Specifications

Specifications

DR3
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q93038
APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, apoptosis inducing receptor, apoptosis-inducing receptor AIR, apoptosis-mediating receptor DR3, apoptosis-mediating receptor TRAMP, death domain receptor 3 soluble form, death receptor beta, lymphocyte-associated receptor of death, protein WSL-1, tumor necrosis f
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
85030, 8718
Flow Cytometry, Western Blot
59204
Unconjugated
TNFRSF25
Lyophilized
TNFRSF25
Mouse myeloma cell line NS0-derived recombit human DR3 isoform 1 Gln25-Phe201
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
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