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TRAIL-R2 (DR5) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523095

Catalog No. PIPA523095


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Description

Description

PA5-23095 targets DR5/TRAILR2 in FACS, ICC, IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-23095 immunogen is synthetic peptide (388 CKWVNKTGRDASVHTLLDALE 407) of DR5/TRAILR2 protein.

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
Specifications

Specifications

TRAIL-R2 (DR5)
Polyclonal
Unconjugated
TNFRSF10B
Liquid
TNFRSF10B
Synthetic peptide (388 CKWVNKTGRDASVHTLLDALE 407) of DR5/TRAILR2 protein.
Protein G
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
O14763
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, Trail receptor 2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8795
Documents
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