DR6, clone: DR-6-04-EC, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119370
CD358 / DR6 (Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses.
|Fusion protein representing amino acids 42-335 of human DR6 linked to the Fc portion of human IgG1.|
|Flow Cytometry, Immunocytochemistry, Immunoprecipitation|
|PBS with 15mM sodium azide; pH 7.4|
|4° C, do not freeze|
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