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DRAM Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141647

Catalog No. 01-675-260


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Description

Description

This antibody is expected to react with canine, monkey and opossum samples based on sequence homology.

DRAM is an important lysosomal membrane protein of the p53 tumor suppressor pathway. It is required for the induction of macroautophagy and as an effector of p53-mediated death. DRAM expression is induced due to cellular stress via endogenous p53 leading to bulk degradation of cytoplasmic components. It is necessary but not sufficient for apoptotic cell death from p53, while over expression of DRAM alone causes minimal cell death. Quantitative PCR revealed that DRAM was significantly down regulated in tumor cell lines by methylation-dependent transcriptional silencing, particularly in cancers lacking other mechanisms of p53 inactivation.
Specifications

Specifications

DRAM
Polyclonal
Unconjugated
DRAM1
Liquid
DRAM1
Synthetic peptide corresponding to residues 50-100 of human DRAM.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8N682, Q9DC58
DRAM, FLJ11259
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
55332, 679937, 71712
Documents
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