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DRAM Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520335

Catalog No. PIPA520335


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Description

Description

A suggested positive control is 293 cell lysate. PA5-20335 can be used with blocking peptide PEP-0455.

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Specifications

Specifications

DRAM
Polyclonal
Unconjugated
DRAM1
Liquid
DRAM1
A 16 amino acid peptide from near the carboxy terminus of human DRAM.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8N682, Q9DC58
DRAM; DNA damage-regulated autophagy modulator protein 1; damage-regulated autophagy modulator
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
55332, 679937, 71712
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