Rb (Cleaved DRb-p70) Mouse anti-Human, Mouse, Clone: 172C1094, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141186
Suggested positive control: camptothecin-treated HL-60 (24 hr).The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5).
|Rb (Cleaved DRb-p70)|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Cleaved Rb, Rb-p70, DRb-p70, delta RB-p70, pRb, pp110|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|Caspase-3-induced cleavage site of human Rb.|
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