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Rb (Cleaved DRb-p70) Mouse anti-Human, Mouse, Clone: 172C1094, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141186

Catalog No. 01-676-588


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Description

Description

Suggested positive control: camptothecin-treated HL-60 (24 hr).

The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5).
Specifications

Specifications

Rb (Cleaved DRb-p70)
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P06400, P13405
Cleaved Rb, Rb-p70, DRb-p70, delta RB-p70, pRb, pp110
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
19645, 5925
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
172C1094
Unconjugated
RB1
Liquid
RB1
Caspase-3-induced cleavage site of human Rb.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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