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DTL Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524453

Catalog No. PIPA524453


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Description

Description

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the  ft.K+4 ft. motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the  ft.Lys-164 ft. monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Specifications

Specifications

DTL
Polyclonal
Unconjugated
DTL
Liquid
DTL
KLH conjugated synthetic peptide between 229-256 amino acids from the central region of human DTL
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry, Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
Q9NZJ0, Q3TLR7
CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51514, 76843
Documents
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