DTL Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA524453
DescriptionSubstrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the ft.K+4 ft. motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the ft.Lys-164 ft. monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
|KLH conjugated synthetic peptide between 229-256 amino acids from the central region of human DTL|
|Antigen Affinity Chromatography, Protein A|
|Flow Cytometry, Western Blot|
|PBS with 0.09% sodium azide|
|CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated|
|-20° C, Avoid Freeze/Thaw Cycles|
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