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OTUD5 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523355

Catalog No. PIPA523355


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Description

Description

DUBA, also known as OTU domain-containing protein 5, is a de-ubiquitinating enzyme belonging to the OTU5 family and DUB subfamily characterized by an ovarian tumor (OTU) domain. DUBA is a protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. This de-ubiquitinating activity is directed towards  ft.Lys-63 ft.-linked polyubiquitin chains and acts via TRAF3 de-ubiquitination and subsequent suppression of type I interferon (IFN) production. DUBA acts as a negative regulator of the innate immune system. It is generally inhibited by N-ethyl-maleimide (NEM). Expression of this enzyme is seen in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. DUBA is induced by bacterial lipopolysaccharides (LPS) in bone marrow-derived macrophages.
Specifications

Specifications

OTUD5
Polyclonal
Unconjugated
OTUD5
Liquid
OTUD5
Synthetic peptide (552 EYLDSMKKNKVHRDPPPDK 570) of DUBA protein.
Protein A
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q96G74, Q3U2S4, Q2YDU3
DUBA, OTU domain-containing protein 5, deubiquinating enzyme A, deubiquitinating enzyme A
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
363452, 54644, 55593
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