OTUD5 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523355
DescriptionDUBA, also known as OTU domain-containing protein 5, is a de-ubiquitinating enzyme belonging to the OTU5 family and DUB subfamily characterized by an ovarian tumor (OTU) domain. DUBA is a protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. This de-ubiquitinating activity is directed towards ft.Lys-63 ft.-linked polyubiquitin chains and acts via TRAF3 de-ubiquitination and subsequent suppression of type I interferon (IFN) production. DUBA acts as a negative regulator of the innate immune system. It is generally inhibited by N-ethyl-maleimide (NEM). Expression of this enzyme is seen in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. DUBA is induced by bacterial lipopolysaccharides (LPS) in bone marrow-derived macrophages.
|Synthetic peptide (552 EYLDSMKKNKVHRDPPPDK 570) of DUBA protein.|
|Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q96G74, Q3U2S4, Q2YDU3|
|DUBA, OTU domain-containing protein 5, deubiquinating enzyme A, deubiquitinating enzyme A|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|363452, 54644, 55593|
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