DUSP8 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141638
Suggested positive control: Hela whole cell extract.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein kinase superfamily , which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predomitly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
|Synthetic peptide corresponding to residues 250-300 of human DUSP8.|
|PBS with 0.05% BSA and 0.05% sodium azide|
|C11orf81, FLJ42476, FLJ42958, HB5, HVH-5, HVH8|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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