DUT Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141084
Suggested positive control: antigen standard for DUT (transient overexpression lysate), Hela whole cell extract, HeLa.Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that functions in the hydrolysis of dUTP to dUMP and pyrophosphate. Canman and co-workers have demonstrated that, in certain human tumor cell lines, increased levels of dUTPase are responsible for an increase in resistance to the cancer chemotherapeutic agent fluorodeoxyuridine (FUdR), a thymidine synthase inhibitor. Two distinct forms of dUTPase exist in humans. Cellular fractionation experiments suggest that the more abundant, lower mass form of dUTPase (DUT-N) localizes in the nucleus, while the higher mass form (DUT-M) is associated with the mitochondria.
|Synthetic peptides, KLH conjugated, corresponding to residues 25-44 and 113-130 of human DUT-N.|
|PBS with 0.05% BSA and 0.02% sodium azide|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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