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Dynactin 1 Mouse anti-Human, Clone: 6B11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA518308

Catalog No. PIMA518308



Description

Description

This antibody detects endogenous levels of DCTN1 at a molecular weight of 150 kDa and does not cross-react with related proteins. Purity is >95% by SDS-PAGE.

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB which is also known as distal spinal and bulbar muscular atrophy.
Specifications

Specifications

Dynactin 1
Monoclonal
Unconjugated
DCTN1
Liquid
DCTN1
Synthetic peptide corresponding to the N-terminal of human Dynactin 1
Antigen affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunoprecipitation, Western Blot
6B11
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q14203
150 kDa dynein-associated polypeptide DAP-150, Dynactin 1, DCTN1, P135, DP-150, DAP-150, DCTN 1
Mouse
IgG2b
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
1639
Documents
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