DYRK1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521124
A suggested positive control is Hela cell lysate. PA5-21124 can be used with blocking peptide PEP-1238.DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
|A 17 amino acid peptide near the carboxy terminus of human DYRK1A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q13627, Q61214, Q63470|
|DYRK, DYRK1, HP86, MNB, MNBH, MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; dual specificity tyrosine-phosphorylation-regulated kinase 1A; hMNB; mnb protein kinase homolog hp86; protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|13548, 1859, 25255|
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