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DYRK2 Mouse anti-Human, Rat, Clone: 599542, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524269

Catalog No. PIMA524269


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Description

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
Specifications

Specifications

DYRK2
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q92630
dual specificity tyrosine-phosphorylation-regulated kinase 2
Mouse
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
314862, 8445
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
599542
Unconjugated
DYRK2
Lyophilized
DYRK2
E. coli-derived recombit human DYRK2 (aa 1-107)
Protein A/G
RUO
Antibody
Monoclonal
Human, Rat
Documents
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