β-Dystroglycan Mouse anti-Human, Unlabeled, Clone: 56, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 612090

Catalog No. BDB612090

Description

Formation of the neuromuscular junction (NMJ) requires interaction between specific extracellular matrix proteins, intracellular cytoskeletal elements, and clustering of specific neurotransmitter receptors. Dystroglycans, α-dystroglycan and β-dystroglycan, are two members of the dystrophin-associated complex, an essential element of NMJs. These proteins are encoded by the same gene, but posttranslationally cleaved to produce a 156kDa extracellular peripheral membrane protein, α-dystroglycan, and a 43kDa transmembrane protein, β-dystroglycan. Dystroglycans are expressed highest in heart and muscle, but are also found in non-muscle tissues. α-dystroglycan may interact with agrin to facilitate AChR clustering at NMJs, and has been implicated as a laminin receptor. β-dystroglycan recruits dystrophin to the sarcolemma, and interactions between β-dystroglycan and caveolin-3 may regulate this recruitment. Mice deficient in dystroglycans have severly disorganized NMJs, and have reductions in the concentration of laminin, perlecan, and AChE at the synaptic basement membrane of NMJs. Thus, dystroglycans may have important extracellular and intracellular roles during NMJ assembly.

Host Species: Mouse
Clone: 56
Isotype: IgG2a
Species Reactivity [for Features Main]: Human
Immunogen: Human β-Dystroglycan aa. 655-767

Immunofluorescence, Western Blotting

Specifications

• Antigen: β-Dystroglycan
• Classification: Monoclonal
• Concentration: 250μg/mL
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 56
• Conjugate: Unconjugated
• Immunogen: Human β-Dystroglycan aa. 655-767
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Human

For Research Use Only.