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E2F3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527670

Catalog No. PIPA527670


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Description

Description

PA5-27670 targets E2F3 in WB applications and shows reactivity with Human samples. The PA5-27670 immunogen is recombit fragment corresponding to a region within amino acids 153 and 409 of Human E2F3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.
Specifications

Specifications

E2F3
Polyclonal
Unconjugated
E2F3
Liquid
E2F3
Recombit fragment corresponding to a region within amino acids 153 and 409 of Human E2F3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.28 mg/mL
PBS with 10% glycerol and 0.01% thimerosal; pH 7
O00716
E2F-3, transcription factor E2F3
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
1871
Documents
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