E2F5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA129137
PA1-29139 detects HSP90 from human, rat, mouse samples. PA1-29139 has been successfully used in immunofluorescence, immunohistochemistry (paraffin tissue), Western blot applications. The PA1-29139 immunogen is Synthetic peptide corresponding to residuesThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.
|Synthetic peptide corresponding to the N-terminus of human E2F-5 protein|
|Human, Mouse, Rat|
|PBS with 0.2% BSA and 0.1% sodium azide; pH 7.4|
|Q15329, Q61502, Q62814|
|4° C, do not freeze|
|116651, 13559, 1875|
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