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EAR2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527135

Catalog No. PIPA527135


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Description

Description

PA5-27137 targets FACL4 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples. The PA5-27137 immunogen is synthetic peptide corresponding to a region within amino acids 649 and 711 of Human FACL4.

Transcription factor predomitly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5 ft.-AGGTCA-3 ft. direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintece of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Specifications

Specifications

EAR2
Polyclonal
Unconjugated
NR2F6
Liquid
NR2F6
Synthetic peptide contain a sequence corresponding to a region within amino acids 344 and 404 of NR2F6
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
P10588, P43136
EAR-2, EAR2, ERBAL2, ERBA-related gene-2, V-erbA-related protein 2, nuclear receptor V-erbA-related, nuclear receptor subfamily 2 group F member 6, v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
13864, 2063
Documents
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