Epstein Barr Virus Nuclear Antigen 3A, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA130653
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.PA1-30653 detects EBNA 3A from virus samples.PA1-30653 has been successfully used in Western blot applications.The PA1-30653 immunogen is: Full length viral protein.
|Epstein-Barr Virus Nuclear Antigen 3A|
|PBS with 0.08% sodium azide|
|EBV nuclear antigen 1, EBNA-3A|
|Full length viral protein.|
|Ammonium sulfate precipitation|
|Store at -20°C|
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