Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
EBP50 Mouse anti-Human, Unlabeled, Clone: 6, BD
Mouse Monoclonal Antibody
Specifications
| Antigen | EBP50 |
|---|---|
| Clone | 6 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
Description
Integral plasma membrane proteins are stabilized by linkages to the cortical actin cytoskeleton, which structurally supports the membrane and contributes to processes such as endocytosis, exocytosis, and transmembrane signaling. The ERM (ezrin-radixin-moesin) family of proteins provides these structural linkages. The ERM proteins contain a 300-residue N-terminal domain, a 170-residue α-helical region, and a C-terminal 100-residue domain that contains F-actin binding sites. The N-terminal domain interacts with the cytoplasmic domain of CD44, the regulatory subunit of PKA, and the PDZ domain containing ERM-binding phosphoprotein (EBP-50). In polarized epithelial cells, EBP-50 links ezrin and the cytoplasmic regions of transmembrane proteins such as the cystic fibrosis transmembrane conductance regulator (CFTR) and the β2-adrenergic receptor. EBP50 contains two PDZ domains followed by a C-terminal tail. It colocalizes with ezrin in apical microvilli and is also thought to interact with the Na+-H+ exchanger NHE3 to confer cAMP-mediated inhibition of Na+-H+ exchange. Thus, EBP-50 mediates membrane attachment to the cytoskeleton and may also function in the regulation of ion exchange.
Host Species: Mouse
Clone: 6
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Human EBP50 aa. 128-249
Formula Weight [Chemical]: 50-53kDa
Immunofluorescence, Western Blotting
Specifications
| EBP50 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 6 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human | |
| Human EBP50 aa. 128-249 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
Spot an opportunity for improvement?
Provide Content Correction
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title