S1PR2 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523208
DescriptionS1P2 is a membrane protein belonging to the EDG family of extracellular G protein coupled receptors. It acts as a receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) and participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. It shares 92% amino acid identity with rat H218 and approximately 44% identity with the human S1P receptors Edg1 and Edg3. Though the role of S1P2 in vascular permeability is not clear, reports suggest that it regulates PTEN by a Rho GTPase-dependent pathway to inhibit cell migration. S1P2 also plays an important role in normal vascularization and hypoxia-triggered pathological angiogenesis of the mouse retina. The gene for human S1P2 protein is localized on chromosomal region 19p13.2. The protein is usually expressed in human brain and heart.
|Synthetic peptide (325 LLPLRSSSSLERGMHMPTS 343) of Edg5/S1P2 protein.|
|Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|O95136, P52592, P47752|
|AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, S1P receptor 2, S1P receptor EDG5, S1P receptor Edg-5, endothelial differentiation G-protein coupled receptor 5, endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, sphingosine 1-phosphate receptor 2, sphingosine 1-phosphate receptor Edg-5|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|14739, 29415, 9294|
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