EDG8 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112495
A suggested positive control for this product is RH7777 cells transfected with full length EDG8 protein.Endothelial Cell Differentiation Gene-8 (EDG-8) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-8 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-8 is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.
|Synthetic peptide corresponding to the C-terminus of human EDG-8.|
|Ammonium sulfate precipitation|
|PBS with 0.08% sodium azide|
|EDG8, Edg-8, S1P5, SPPR-1, SPPR-2|
|-20° C, Avoid Freeze/Thaw Cycles|
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