EFCAB4B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521060
A suggested positive control is mouse kidney tissue lysate. PA5-21060 can be used with blocking peptide PEP-1174.EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
|A 14 amino acid peptide near the carboxy terminus of human EFCAB4B.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CRACR2A; CRAC channel regulator 2A; EF-hand calcium-binding domain-containing protein 4B; calcium release-activated calcium channel regulator 2A|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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