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EFCAB4B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521060

Catalog No. PIPA521060


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Description

Description

A suggested positive control is mouse kidney tissue lysate. PA5-21060 can be used with blocking peptide PEP-1174.

EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
Specifications

Specifications

EFCAB4B
Polyclonal
Unconjugated
CRACR2A
Liquid
CRACR2A
A 14 amino acid peptide near the carboxy terminus of human EFCAB4B.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9BSW2, Q3UP38
CRACR2A; CRAC channel regulator 2A; EF-hand calcium-binding domain-containing protein 4B; calcium release-activated calcium channel regulator 2A
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
381812, 84766
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