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EGF Mouse anti-Human, Clone: 10827, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523704

Catalog No. PIMA523704


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Description

Description

In sandwich ELISAs, no cross-reactivity or interference is observed with recombit mouse (rm) EGF, bovine FGF acidic, bovine FGF basic, recombit human (rh) G-CSF, rhGM-CSF, rmGM-CSF, rhLIF, human PDGF, porcine PDGF, rhTGF&No.x2011; alpha, hTGF-beta 1, pTGF-beta 1, rhTGF-beta 1, porcine TGF-beta 1.2, porcine TGF-beta 2, rhTNF-alpha, or rhTNF-beta. Reconstitute at 0.5 mg/mL in sterile PBS.

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
Specifications

Specifications

EGF
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P01133
Epidermal Growth Factor, URG, Urogastrone, HOMG4, URG, beta-urogastrone, pro-epidermal growth factor
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1950
ELISA, Immunohistochemistry
10827
Unconjugated
EGF
Lyophilized
EGF
E. coli-derived recombit human EGF
Protein A/G
RUO
Antibody
Monoclonal
Human
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