EGF Mouse anti-Human, Clone: 10827, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523704
In sandwich ELISAs, no cross-reactivity or interference is observed with recombit mouse (rm) EGF, bovine FGF acidic, bovine FGF basic, recombit human (rh) G-CSF, rhGM-CSF, rmGM-CSF, rhLIF, human PDGF, porcine PDGF, rhTGF&No.x2011; alpha, hTGF-beta 1, pTGF-beta 1, rhTGF-beta 1, porcine TGF-beta 1.2, porcine TGF-beta 2, rhTNF-alpha, or rhTNF-beta. Reconstitute at 0.5 mg/mL in sterile PBS.EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
|PBS with 5% trehalose and No Preservative|
|Epidermal Growth Factor, URG, Urogastrone, HOMG4, URG, beta-urogastrone, pro-epidermal growth factor|
|-20° C, Avoid Freeze/Thaw Cycles|
|E. coli-derived recombit human EGF|
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