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eIF-5a Mouse, Unlabeled, Clone: 26, BD

Mouse Monoclonal Antibody

$207.00 - $415.00

Specifications

Antigen eIF-5a
Isotype IgG1
Immunogen Human eIF-5a aa. 58-154
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611977
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BD Biosciences
611977
150μg Each for $415.00
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BDB611976
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BD Biosciences
611976
50μg Each for $207.00
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Description

Description

Initiation of eukaryotic translation involves a series of reactions mediated by multiple eukaryotic initiation factors (eIFs). However, one member of this family, eIF-5a, may have multiple protein functions. eIF-5a was originally identified as an initiation factor due to its binding of ribosomes, and its stimulation of methionyl-puromycin. Regulation of initiation may not be the major function of eIF-5a, since it functions as a targeting protein for the HIV protein, Rev, and the T-cell leukemia virus type 1 protein, Rex. In Xenopus oocytes, eIF-5a interacts with the nucleoporins Nup214, Nup153, Nup98, and Nup62, and is required for Rev-NES interaction with exportin1. These interactions may be involved with eIF-5a nuclear export of Rev protein, and eIF-5a requirement for Rev-mediated viral RNA export. eIF-5a is ubiquitously expressed, and is the only known eukaryotic protein that contains the post-translationally formed hypusine residue. Modification of eIF-5a with hypusine is coupled to cell proliferation, and disruption of this residue in yeast eIF-5a is lethal. Thus, eIF-5a may be an important nuclear transport protein with conserved function in many species.

Host Species: Mouse
Clone: 26
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human eIF-5a aa. 58-154

Bioimaging, Immunofluorescence, Western Blotting

Specifications

Specifications

eIF-5a
Human eIF-5a aa. 58-154
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
26
250μg/mL

For Research Use Only.

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