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eIF-6 Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611120

Catalog No. BDB611120


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Description

Description

Initiation of eukaryotic translation involves a series of reactions mediated by multiple eukaryotic initiation factors (eIFs). As a prerequisite to initiation, the initiator methionyl-tRNA (Met-tRNAf), in a ternary complex with eIF-2 and GTP, binds to the 40S ribosomal subunit. This 40S preinitiation complex is positioned at the initiation AUG codon to form the 40S initiation complex. This complex is joined by the 60S ribosomal subunit to form the 80S initiation complex, which functions as a peptidyl transferase. Once translation is completed, the
polysomal complex is dismantled with the formation of the free 40S and 60S subunits. eIF-6 is a monomeric protein which binds to the 60S ribosomal subunit and blocks its association with the 40S subunit. The human eIF-6 is expressed in a wide range of tissues and exhibits a significant homology with sequences from S. cerevisiae and Drosophila. The joining of the 60S subunit to the 40S initiation complex requires eIF-5; thus, eIF-5 & -6 may maintain equilibrium between the individual subunits and the 80S complex.

Host Species: Mouse
Clone: 23
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human eIF-6 aa. 17-128
Formula Weight [Chemical]: 27kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

eIF-6
23
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Eukaryotic Initiation Factor-6
Affinity Purified
Human eIF-6 aa. 17-128
50μg
Cell Biology
Primary
Canine, Human, Murine, Rat
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