Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

eIF-6 Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611120

Catalog No. BDB611120

Add to cart



Initiation of eukaryotic translation involves a series of reactions mediated by multiple eukaryotic initiation factors (eIFs). As a prerequisite to initiation, the initiator methionyl-tRNA (Met-tRNAf), in a ternary complex with eIF-2 and GTP, binds to the 40S ribosomal subunit. This 40S preinitiation complex is positioned at the initiation AUG codon to form the 40S initiation complex. This complex is joined by the 60S ribosomal subunit to form the 80S initiation complex, which functions as a peptidyl transferase. Once translation is completed, the
polysomal complex is dismantled with the formation of the free 40S and 60S subunits. eIF-6 is a monomeric protein which binds to the 60S ribosomal subunit and blocks its association with the 40S subunit. The human eIF-6 is expressed in a wide range of tissues and exhibits a significant homology with sequences from S. cerevisiae and Drosophila. The joining of the 60S subunit to the 40S initiation complex requires eIF-5; thus, eIF-5 & -6 may maintain equilibrium between the individual subunits and the 80S complex.

Host Species: Mouse
Clone: 23
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human eIF-6 aa. 17-128
Formula Weight [Chemical]: 27kDa

Immunofluorescence, Western Blotting



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
Eukaryotic Initiation Factor-6
Affinity Purified
Human eIF-6 aa. 17-128
Cell Biology
Canine, Human, Murine, Rat
Product Certifications


Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit