eIF3i Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527582
PA5-27582 targets EIF3 beta in IF and WB applications and shows reactivity with Human samples. The PA5-27582 immunogen is recombit fragment corresponding to a region within amino acids 66 and 325 of Human EIF3 beta. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
|Recombit fragment corresponding to a region within amino acids 66 and 325 of Human EIF3 beta|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 40% glycerol and 0.01% thimerosal; pH 7|
|EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36, TGF-beta receptor-interacting protein 1, TGFbeta receptor-interacting protein 1, eIF-3-beta, eIF3 p36, eukaryotic translation initiation factor 3 subunit 2, eukaryotic translation initiation factor 3 subunit I, eukaryotic translation initiation factor 3, subuni|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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