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eIF3c Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527527

Catalog No. PIPA527527


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Description

Description

PA5-27527 targets eIF3 p110 in WB applications and shows reactivity with Human samples. The PA5-27527 immunogen is recombit fragment corresponding to a region within amino acids 661 and 903 of Human eIF3 p110. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Specifications

Specifications

eIF3c
Polyclonal
Unconjugated
EIF3C
Liquid
EIF3C
Recombit fragment corresponding to a region within amino acids 661 and 903 of Human eIF3 p110
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.9 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q99613
EIF3CL, EIF3S8, eIF3-p110, cell migration-inducing protein 17, eIF3 p110, eukaryotic translation initiation factor 3 subunit 8, eukaryotic translation initiation factor 3 subunit C, eukaryotic translation initiation factor 3, subunit 8 (110kD), eukaryotic translation initiation factor 3
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8663
Documents
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