eIF4A2 Rabbit anti-Canine, Chicken, Human, Mouse, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523264
DescriptioneIF4A2 is a 407 amino acid ATP-dependent RNA helicase, belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the 43S pre-initiation complex of ribosomes. Research is carried out to elucidate the potential role of eIF4A2 in glucose homeostasis and also in type 2 diabetes in the presence of metabolic stress where eIF4A2 controls specific mRNA translation and protein synthesis rate in pancreatic beta-cells. Human eIF4A2 interacts with the NS5B protein of Hepatitis C virus (HCV) and facilitates the genomic RNA synthesis of NS5B protein by unwinding the secondary structure of the HCV genome. It is ubiquitously expressed in most of normal tissues, but in variable amount.
|Synthetic peptide (69 KGYDVIAQAQSGTGKTAT 86) of eIF4A2 protein.|
|Antigen affinity chromatography|
|Canine, Chicken, Human, Mouse, Non-human primate|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q8JFP1, Q14240, P10630|
|BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2, eukaryotic initiation factor 4A-II, eukaryotic translation initiation factor 4A|
|-20° C, Avoid Freeze/Thaw Cycles|
|13682, 1974, 395232, 488118|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok