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eIF4A2 Rabbit anti-Canine, Chicken, Human, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523264

Catalog No. PIPA523264


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Description

Description

eIF4A2 is a 407 amino acid ATP-dependent RNA helicase, belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the 43S pre-initiation complex of ribosomes. Research is carried out to elucidate the potential role of eIF4A2 in glucose homeostasis and also in type 2 diabetes in the presence of metabolic stress where eIF4A2 controls specific mRNA translation and protein synthesis rate in pancreatic beta-cells. Human eIF4A2 interacts with the NS5B protein of Hepatitis C virus (HCV) and facilitates the genomic RNA synthesis of NS5B protein by unwinding the secondary structure of the HCV genome. It is ubiquitously expressed in most of normal tissues, but in variable amount.
Specifications

Specifications

eIF4A2
Polyclonal
Unconjugated
EIF4A2
Liquid
EIF4A2, MIR1248
Synthetic peptide (69 KGYDVIAQAQSGTGKTAT 86) of eIF4A2 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Chicken, Human, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8JFP1, Q14240, P10630
BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2, eukaryotic initiation factor 4A-II, eukaryotic translation initiation factor 4A
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
13682, 1974, 395232, 488118
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