Neutrophil elastase Mouse anti-Human, Clone: 265-3K1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140220
MA1-40220 detects Elastase from human samples. MA1-40220 has been successfully used in ELISA, Immunohistochemistry (Paraffin), Immunofluorescence, Flow Cytometry and Western blot applications. The MA1-40220 immunogen is human leukocyte elastase.Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Leukocyte elastase, a major serine proteinase in man, is predomitly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is regulated by serine proteinase inhibitors. During inflammation, elastase is released and rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. When secreted at sites of inflammation elastase can cause severe tissue damage. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a process that occurs in part through TLR4.
|PBS with 0.1% BSA and 0.02% sodium azide|
|ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Human leukocyte elastase.|
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