EMAP II Mouse anti-Human, Rat, Clone: 546-2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140228
MA1-40228 detects EMAP-II from human and rat samples. MA1-40228 has been successfully used in ELISA, flow cytometry, immunohistochemistry (paraffin), and Western blot applications. The MA1-40228 immunogen is human EMAP-II polypeptide.EMAP II is an antiangiogenic and proinflammatory cytokine (expressed by microglia/macrophages) that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. EMAP II appears to be a profound modulator of inflammatory reactions of the innate immune system and might participate in a variety of pathogenic immune processes in the mammalian brain. EMAP II is a potential mediator of inflammatory responses in autoimmunity and a considered target to stage reactions of monocytic lineage cells in inflammatory reactions. The precursor of this cytokine is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-EMAP II may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells. In normal tissues EMAP II is expressed in endocrine organs, in cells of neuroendocrine origin, but also in tissues with high cell turnover. Under pathophysiological conditions EMAP II has several functions. It triggers the recruitment of macrophages by elevating cytosolic-free Ca2+ concentrations, it stimulates leukocyte chemotaxis, it induces the expression of TNF-alpha and tissue factor (TF) by monocytes and myeloperoxidase (MPO) by polymorphonuclear cells (PNMs). Furthermore it stimulates the release of von Willebrand-factor, P- and E-selectin by endothelial cells and EMAP II induces endothelial programmed cell death in vitro.
|PBS with 0.1% BSA and 0.02% sodium azide|
|ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Recombit human EMAP-II|
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