RECA-1 Mouse anti-Rat, Clone: RECA-1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140240
MA1-40240 detects Endothelial cell antigen from rat samples. MA1-40240 has been successfully used in immunohistochemistry (frozen), immunohistochemistry (paraffin), flow cytometry and immunofluorescence applications. The MA1-40240 immunogen is cell surface antigen. Positive control: Glomerular endothelial cells, RHEC cell line; Negative control: Vascular smooth muscle cells, fibroblastsRECA-1 is a cell surface antigen which is expressed by all rat endothelial cells. The endothelium is the thin layer of cells that line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. Endothelial cells (EC) line the interior of all blood vessels and are the key players in the angiogenesis cascade. EC are the first cells and barrier that vehicles or medicines encounter after systemic delivery. Furthermore, they have a signaling function to the cells of the immune system to indicate the status of the surrounding tissue. RECA-1is at least reactive with the rat MHC-haplotype; Lewis (TR-11), BN (RT-1n) and OA (RT-1u). RECA-1 antibody has been successfully applied in staining of viable endothelial cells in vitro, and of vascular endothelium in vivo. No reactivity of the RECA-1 monoclonal antibody was seen with other cell types e.g. fibroblasts, leukocytes and non-endothelial stromal cells nor with other various tested species other than rat e.g. mouse, rabbit, sheep, goat and human. RECA-1 is a promising antibody for rat endothelial cell studies, and in particular for further defining nature and function of endothelial cell-specific antigens.
|PBS with 0.1% BSA and 0.02% sodium azide|
|Endothelial cells; Endothelium Cell Antigen-1; Endothelial cell marker; Pan endothelial cells|
|Cell surface antigen.|
|Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
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