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Endothelin 1 Receptor Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611252

Catalog No. BDB611252


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Description

Description

Endothelin-1 (ET-1) is a potent vasoconstrictor that is secreted by vascular endothelial cells. ET-1, ET-2, ET-3, and endothelin β are members of a family of related peptides. All are 21 amino acid peptides with two disulfide bridges. ET-1 and ET-2 differ by only two residues, while ET-3 differs from both by six residues. ET-1 and ET-2 are highly effective on vascular smooth muscle, while the effects of ET-3 are minimal. ET-1 and its precursor, big ET-1, are the primary forms present in the circulation. Circulating ET-1 plays a pathologic role in the etiology of hypertension and antagonists are utilized in the treatment of this disease. The ET-1 receptor is a seven-transmembrane-domain receptor of the G-protein-coupled family that signals via transient increases in intracellular Ca2+. It is primarily expressed in lung and heart and is detected at lower levels in liver, brain, muscle, and kidney. ET-1 receptor interacts with ET-1, ET-2, and ET-3. However, it has a 2-3 fold higher affinity for ET-1 than ET-2 and the affinity for ET-3 is more than 100 fold lower. Thus, ligation of the ET-1 receptor by ET-1 induces increased intracellular Ca2+ that signals to promote vasoconstriction.

Host Species: Mouse
Clone: 16
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat Endothelin 1 Receptor aa. 230-352
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Endothelin 1 Receptor
16
Unconjugated
Affinity Purified
Rat Endothelin 1 Receptor aa. 230-352
50μg
Cell Biology
Primary
Fly, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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