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NSE Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527452

Catalog No. PIPA527452


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Description

Description

PA5-27453 targets GPT in WB applications and shows reactivity with Human and mouse samples. The PA5-27453 immunogen is recombit fragment corresponding to a region within amino acids 6 and 188 of Human GPT.

Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are injured. NSE is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or alternately as enolase alpha, beta and gamma. The alpha-subunit is expressed in most tissues, the beta-subunit only in muscle, and the gamma-subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms. Since neurons require a great deal of energy, they are very rich in glycolytic enzymes such a GAPDH and NSE. Antibodies to NSE protein are useful to identify neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Further, NSE is found in elevated concentrations in plasma and certain neoplasias that include pediatric neuroblastoma and small cell lung cancer.
Specifications

Specifications

NSE
Polyclonal
Unconjugated
ENO2
Liquid
ENO2
Recombit fragment corresponding to a region within amino acids 1 and 268 of Human ENO2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.56 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P07323 , P09104, P17183
NSE, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolyase, gamma-enolase, neural enolase, neuron specific gamma enolase, neuron-specific enolase, neurone-specific enolase
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
13807, 2026, 24334
Documents
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