NSE Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527452
PA5-27452 targets ENO2 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-27452 immunogen is recombit fragment corresponding to a region within amino acids 1 and 268 of Human ENO2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are injured. NSE is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or alternately as enolase alpha, beta and gamma. The alpha-subunit is expressed in most tissues, the beta-subunit only in muscle, and the gamma-subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms. Since neurons require a great deal of energy, they are very rich in glycolytic enzymes such a GAPDH and NSE. Antibodies to NSE protein are useful to identify neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Further, NSE is found in elevated concentrations in plasma and certain neoplasias that include pediatric neuroblastoma and small cell lung cancer.
|Recombit fragment corresponding to a region within amino acids 1 and 268 of Human ENO2|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|P07323 , P09104, P17183|
|NSE, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolyase, gamma-enolase, neural enolase, neuron specific gamma enolase, neuron-specific enolase, neurone-specific enolase|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|13807, 2026, 24334|
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