Epstein Barr Virus Nuclear Antigen 1 Goat anti-Virus, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA17497
The PA1-7497 antibody detects Epstein-Barr nuclear antigen (EBNA-1). PA1-7497 has been successfully used in ELISA and Western blot applications. Potential applications for PA1-7497 include fluorescence microscopy and immunohistochemistry. The PA1-7497 antibody was raised against recombit EBNA-1.Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin ft.s disease and Burkitt ft.s Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all maligcies associated with EBV.
|Epstein Barr Virus Nuclear Antigen 1|
|Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|ELISA, Western Blot|
|PBS with 0.1% sodium azide; pH 7.2|
|EBV nuclear antigen 1; EBNA-1|
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