Epstein Barr Virus Nuclear Antigen 1 Mouse anti-Virus, Clone: E1-2.5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119238
This antibody recognizes the repetitive Gly-Ala region of the Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1).Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin ft.s disease and Burkitt ft.s Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all maligcies associated with EBV.
|Epstein Barr Virus Nuclear Antigen 1|
|PBS with 15mM sodium azide; pH 7.4|
|EBV nuclear antigen 1; EBNA-1|
|Epstein-Baar nuclear antigen 1.|
|4° C, do not freeze|
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