ErbB2 (HER-2) Mouse anti-Mammalia, Clone: CB11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA135720
Specific binding has been demonstrated by immunoprecipitation with c-erbB-2 oncoprotein from SKBr3 cells. A positive control of breast adenocarcinoma is recommended.This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
|Synthetic internal domain of the C-erbB-2 oncoprotein.|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|13866, 2064, 24337, 403883|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|tissue culture supernatant with 0.1% sodium azide|
|O18735, P04626, P70424, P06494|
|Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, MLN19, NEU, NGL, c-erb B2/neu protein, herstatin, metas|
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