Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

ErbB2 (HER-2) Mouse anti-Human, Clone: N24, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112691

Catalog No. 01-674-040


Add to cart

Description

Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

MA1-12691 detects HER-2 in human samples.MA1-12691 has been successfully used in immunofluorescence and immunoprecipitation procedures.The MA1-12691 immunogen is intact SKBR-3 breast cancer cells.
Specifications

Specifications

ErbB2 (HER-2)
Monoclonal
1 mg/mL
PBS with no preservative
P04626
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, MLN19, NEU, NGL, c-erb B2/neu protein, herstatin, metas
Mouse
IgG1
100 μg
-20°C
Primary
2064
Immunocytochemistry, Immunofluorescence, Immunoprecipitation
N24
Unconjugated
ERBB2
Liquid
ERBB2
Intact SKBR-3 breast cancer cells.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit