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ErbB3 Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA186644

Catalog No. PIPA186644


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Description

Description

Predicted to react with dog, mouse and rat based on sequence homology. In Western blot, this antibody detects a band at ~150 kDa in Jurkat cell lysates. A minimum incubation time of 1 hour is recommended with this antibody. Goat anti Human Erb3 antibody recognizes the human Receptor tyrosine-protein kinase erbB-3, also known as ErbB3, Proto-oncogene-like protein c-ErbB-3 or Tyrosine kinase-type cell surface receptor HER3.

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Specifications

Specifications

ErbB3
Polyclonal
Unconjugated
ERBB3
Liquid
ERBB3
peptide sequence C-HSRLFPKANAQRT corresponding to the C-terminal of ErbB3 isoform 1(NP_001973.2).
Affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P21860
ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Goat
IgG
100 μg
4°C or -20°C if preferred
Primary
2065
Documents
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