ERK3 Mouse, Unlabeled, Clone: 30, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610105
The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK3 is a 63kDa family member that is 43% homologous to ERK1 and ERK2. A 97kDa ERK3 isoform has also been described which possesses an additional 178 amino acids.
Host Species: Mouse
Species Reactivity: Mouse
Immunogen: Rat ERK3 aa. 399-543
Formula Weight [Chemical]: 62kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Canine, Chicken, Human, Murine, Rat|
|Immunofluorescence, Immunoprecipitation, Western Blot|
|Rat ERK3 aa. 399-543|
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