ERO1L Rabbit anti-Human, Mouse, Rat, HRP, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522745
This ERO1L antibody is useful for Western Blot, where a band ~57 kDa is observed. Depending on the samples used ERO1L can also appear as a doublet which is believed to represent the oxidized and reduced forms of the protein. Suggested positive control: 293T, INS-1, and MIN6 cell lysate.Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes.
|A synthetic peptide made the the N-terminal region of the human protein.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 1% BSA and no preservative|
|Q96HE7, Q8R180, Q8R4A1|
|UNQ434/PRO865, ERO1-alpha, ERO1A, ERO1-L, ERO1-L-alpha, ERO1-like protein alpha, endoplasmic oxidoreductin-1-like protein, oxidoreductin-1-L-alpha|
|4° C, store in dark|
|171562, 30001, 50527|
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