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ERP29 Rabbit anti-Bovine, Canine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3011

Catalog No. PA3011


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Description

Description

PA3-011 detects ERp29 protein in rat, mouse, hamster, canine, non-human primate, bovine and guinea pig samples. PA3-011 has successfully been used in immunofluorescence, immunoprecipitation and Western blot procedures. By Western blot, this antibody detects an ~29 kDa protein representing ERp29 in rat liver homogenate. Immunofluorescence data demonstrates that ERp29 is localized to the ER of rat thyrocytes using PA3-011. The PA3-011 immunogen was a 6-histidine epitope tagged full length recombit ERp29 protein.

Proper protein folding and post-translational modifications are essential for secretory protein export out of the endoplasmic reticulum. This task is accomplished by chaperone proteins such as protein disulfide isomerase (PDI), GRP94, and BiP. A recently characterized protein, designated ERp29, is closely related to these chaperone proteins and appears to be up regulated during ER stress conditions. ERp29 is a 259-residue protein that is encoded by a gene on chromosome 12 in humans. This soluble protein is localized to the lumen of the endoplasmic reticulum in all mammalian cells. Research has shown that there are two primary domains within ERp29. The first is the C-terminal region that is a novel, all helical, fold that is most likely involved with ERp29 retention to the ER. The second is the N-terminal region that resembles that of PDI’s thioredoxin module.
Specifications

Specifications

ERp29
Polyclonal
whole serum with 0.02% sodium azide
P81623, P30040, P57759, P52555
chromosome 12 open reading frame 8, endoplasmic reticulum lumenal protein ERp28
Rabbit
IgG
RUO
Antibody
Polyclonal
Bovine, Canine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Rat
Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
ERP29
Liquid
ERP29
6-histidine epitope tagged full length recombit rat ERp29.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100731699, 100762501, 10961, 117030, 477482, 613357, 67397
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