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Estrogen Receptor alpha Mouse anti-Human, Mouse, Clone: AER311, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112600

Catalog No. 01-674-368


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Description

Description

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Specifications

Specifications

Estrogen Receptor alpha
Monoclonal
1.0 mg/mL
PBS with 0.08% sodium azide
P03372, P19785
ER
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
13982, 2099
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
AER311
Unconjugated
ESR1
Liquid
ESR1
Estrogen receptors from calf uterus.
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
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