Estrogen Receptor alpha Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA137651
This antibody is predicted to react with porcine based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is breast carcinoma.Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
|Estrogen Receptor alpha|
|PBS with 1% BSA and 0.099% sodium azide; pH 7.6|
|ER, ESR, ESRA, Era, NR3A1, ER-alpha, estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor, estrogen receptor alpha 3*,4,5,6,7*/822 isoform, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform, estrogen recepto|
|-20° C, Avoid Freeze/Thaw Cycles|
|Synthetic peptide derived from C-terminus of human estrogen receptor.|
|Antigen affinity chromatography|
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