ESRRA Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1314
PA1-314 detects human ERR1 from transfected cells and shows no cross-reactivity to ERR3. PA1-314 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~52 kDa protein representing ERR1 from COS-7 transfected cells. An unidentified band is seen at ~37 kDa. The PA1-314 immunogen is a synthetic peptide corresponding to the residues M(1) S S Q V V G I E P L Y I K A E(16) of human ERR1. This sequence is completely conserved between canine, human, mouse and rat. This immunizing peptide (PEP-231) can be used for neutralization and control experiments.Estrogen-related receptor alpha 1 (ERR alpha, ERR1) is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members share an almost identical DNA-binding domain, which has 68% amino acid identity with that of estrogen receptor. This protein binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5 ft.-tnaaggtca-3 ft. can bind to the medium-chain acyl coenzyme a dehydrogenase (mcad) response element nrre-1 and may act as an important regulator of mcad promoter. Studies have shown that ERR1 functions a metabolic regulator and is often expressed in tissues that preferentially metabolize fatty acids. The corresponding gene for the ERR1 is NR3B1.
|Synthetic peptide corresponding to the residues M(1) S S Q V V G I E P L Y I K A E(16) of human ERR1.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Estrogen-Related Receptor Alpha 1, ERR alpha, Steroid hormone receptor ERR1, Estrogen-related receptor alpha, ERR-alpha, Estrogen receptor-like 1|
|-20° C, Avoid Freeze/Thaw Cycles|
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