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ESRRA Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1314

Catalog No. PA1314


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Description

Description

PA1-314 detects human ERR1 from transfected cells and shows no cross-reactivity to ERR3. PA1-314 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~52 kDa protein representing ERR1 from COS-7 transfected cells. An unidentified band is seen at ~37 kDa. The PA1-314 immunogen is a synthetic peptide corresponding to the residues M(1) S S Q V V G I E P L Y I K A E(16) of human ERR1. This sequence is completely conserved between canine, human, mouse and rat. This immunizing peptide (PEP-231) can be used for neutralization and control experiments.

Estrogen-related receptor alpha 1 (ERR alpha, ERR1) is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members share an almost identical DNA-binding domain, which has 68% amino acid identity with that of estrogen receptor. This protein binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5 ft.-tnaaggtca-3 ft. can bind to the medium-chain acyl coenzyme a dehydrogenase (mcad) response element nrre-1 and may act as an important regulator of mcad promoter. Studies have shown that ERR1 functions a metabolic regulator and is often expressed in tissues that preferentially metabolize fatty acids. The corresponding gene for the ERR1 is NR3B1.
Specifications

Specifications

ESRRA
Polyclonal
Unconjugated
ESRRA
Liquid
ESRRA
Synthetic peptide corresponding to the residues M(1) S S Q V V G I E P L Y I K A E(16) of human ERR1.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P11474, Q5QJV7
Estrogen-Related Receptor Alpha 1, ERR alpha, Steroid hormone receptor ERR1, Estrogen-related receptor alpha, ERR-alpha, Estrogen receptor-like 1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2101, 293701
Documents
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