ESRRG Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1316
Estrogen-related receptor gamma (ERR gamma, ERR3, NR3B3) is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA-binding domain, which has 68% amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC-1. ERR3 binds as a homodimer to direct repeats (5’-AGG TCA-3’), to extended half-sites, and to the inverted estrogen response element.The corresponding gene for the ERR3 is NR3B3.PA1-316 detects human and mouse ERR3 from transfected cells and shows no cross-reactivity to ERR1.PA1-316 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~54kDa protein representing ERR1 from COS-7 transfected cells. This antibody is not suitable for 293T cells in Western blot analysis.PA1-316 immunogen is a synthetic peptide corresponding to residues D(401) Y E A G Q H M E D P R R(413) of human ERR3. This sequence is completely conserved between human, mouse and rat. This immunizing peptide (PEP-232) can be used for neutralization and control experiments.
|Synthetic peptide corresponding to residues D(401) Y E A G Q H M E D P R R(413) of human ERR3.|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Estrogen-Related Receptor Gamma, ERR gamma, NR3B3, Estrogen receptor-related protein 3, ERR gamma-2|
|-20° C, Avoid Freeze/Thaw Cycles|
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